Fig. 1 · Structure
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SKF 83959
Dopamine D1-Like Receptor Agonist
SKF 83959 is a selective partial agonist of the dopamine D1-like receptors, demonstrating Ki values of 1.18 nM for D1 and 7.56 nM for D5, while exhibiting lower affinity for D2 and D3 receptors at 920 nM and 399 nM, respectively. Additionally, SKF 83959 acts as a potent allosteric modulator of the sigma-1 receptor. This compound is primarily utilized in research focused on cognitive dysfunction, Alzheimer's disease, and depression, providing insights into potential therapeutic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 80751-85-5 |
| Applications | Dopamine D1-Like Receptor Agonist |
| Formula | C18H20ClNO2 |
| Molecular Weight | 317.81 |
| SMILES | OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.