SKI2496 is a potent GnRH receptor antagonist that exhibits an IC50 of 0.25 nM for human GnRHR, demonstrating high specificity across species with values of 13.2 nM for monkey and 279.2 nM for rat receptors. This compound effectively inhibits Ca2+ influx with an IC50 of 0.76 nM and blocks ERK1/2 phosphorylation with an IC50 of 2.6 nM. SKI2496 is utilized in research focused on sex hormone-dependent disorders, particularly for its ability to reduce serum LH concentrations.
SKI2496 is a potent GnRH receptor antagonist that exhibits an IC50 of 0.25 nM for human GnRHR, demonstrating high specificity across species with values of 13.2 nM for monkey and 279.2 nM for rat receptors. This compound effectively inhibits Ca2+ influx with an IC50 of 0.76 nM and blocks ERK1/2 phosphorylation with an IC50 of 2.6 nM. SKI2496 is utilized in research focused on sex hormone-dependent disorders, particularly for its ability to reduce serum LH concentrations.
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