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SKP-451

K+ Channel Agonist

SKP-451 is an ATP-sensitive potassium (K+) channel agonist that activates the efflux of K+, leading to membrane hyperpolarization and inhibition of calcium influx. This mechanism induces relaxation of vascular smooth muscle, notably in canine coronary arteries, rabbit basilar arteries, and vertebral arteries. In preclinical studies, SKP-451 has demonstrated the ability to lower mean arterial blood pressure in conscious spontaneously hypertensive rats (SHR), making it a valuable tool for cardiovascular disease research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	181137-41-7
Applications	K+ Channel Agonist
Formula	C₁₇H₁₈N₂O₆
Molecular Weight	346.33
SMILES	[O-][N+](C1=CC=C2O[C@](C)(C3OCCO3)C=C(N4C(CCC4)=O)C2=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.