Fig. 1 · Structure
Documents & Downloads
SL-017
SL-017 is a novel photoacoustic sensitizer and a derivative of photofrin B that predominantly targets mitochondria. Upon activation by visible light or ultrasound, SL-017 significantly enhances the production of reactive oxygen species (ROS) and induces a rapid decrease in mitochondrial membrane potential, leading to mitochondrial fragmentation. This reagent demonstrates potential utility in photodynamic therapy and sonodynamic therapy, making it a valuable tool for research focusing on mitochondrial function and therapeutic strategies involving ROS modulation. Additionally, it has been observed that epoxyeicosatrienoic acids (EETs) may mitigate the effects on membrane potential, enhancing its applicability in diverse experimental settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1169831-01-9 |
| Formula | C34H34N2O8 |
| Molecular Weight | 598.64 |
| SMILES | COC1=C2C3=C4C(C5=C(O)C(NCCCN(C)C)=C4C=C(C)C2C(C)=O)=C(C(OC)=CC5=O)C6=C3C(C(C=C6OC)=O)=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.