Fig. 1 · Structure
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SLC6A19-IN-4
B⁰AT1 Inhibitor
SLC6A19-IN-4 is an allosteric-competitive inhibitor targeting B0AT1, with demonstrated inhibitory activity in both human and mouse models, exhibiting IC50 values of 513 nM and 295 nM, respectively. This compound effectively enhances urinary phenylalanine excretion while simultaneously decreasing plasma phenylalanine levels, achieved through its dual action in the intestine and kidneys. SLC6A19-IN-4 is suitable for research applications related to phenylketonuria (PKU) and other disorders associated with SLC6 family transporters.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2962069-39-0 |
| Applications | B⁰AT1 Inhibitor |
| Formula | C16H16F3N3O3 |
| Molecular Weight | 355.31 |
| SMILES | O=C(NCC(N1CC(NCC1)=O)=O)/C=C/C2=CC=C(C=C2)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.