Fig. 1 · Structure
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SLM6
CDK9 Inhibitor
SLM6 is a potent CDK9 inhibitor, specifically targeting the CDK9/cyclin K and CDK9/cyclin T1 complexes with IC50 values of 280 nM and 133 nM, respectively. In addition, SLM6 also effectively inhibits CDK1/cyclin B and CDK2/cyclin A, demonstrating IC50 values below 300 nM. This compound has been shown to induce apoptosis in multiple myeloma cells, making it a valuable tool for research in cancer biology and therapeutic development for hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 22242-91-7 |
| Applications | CDK9 Inhibitor |
| Formula | C12H17N7O4 |
| Molecular Weight | 323.31 |
| SMILES | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C(C(NN)=N)C3=C(N)N=CN=C32)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.