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SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM).
Targets
| ROCK2 | ROCK2 | |||
| 41 nM(Ki) | 60 nM |
| In vitro (25°C) | DMSO | 84 mg/mL (185.63 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+35% PEG 300+2%Tween 80+ddH2O | 6 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.1 mL | 110.49 mL | 220.99 mL |
| 0.5 mM | 4.42 mL | 22.1 mL | 44.2 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
*The above data is based on the productmolecular weight 452.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15239 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 911417-87-3 |
| Formula | C26H24N6O2 |
| M. Wt | 452.51 |
| Purity | >98% |
| Synonyms | SLx 2119, SLx2119, ROCK inhibitor, KD-025 |
| SMILES | CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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