SLx-2119 (KD025)

Catalog No.: A15239

ROCK2 Inhibitor

SLx-2119 (KD025)

SLx-2119 (KD025) Chemical Structure

CAS NO. 911417-87-3

SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM).

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5 mg
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10 mg
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100 mg
$490.00
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Biological Activity

SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM).
Targets
ROCK2 ROCK2
41 nM(Ki)60 nM
In vitro (25°C) DMSO 84 mg/mL (185.63 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+35% PEG 300+2%Tween 80+ddH2O 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.49 mL 220.99 mL
0.5 mM 4.42 mL 22.1 mL 44.2 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15239
Actions Inhibitor
CAS No. 911417-87-3
Formula C26H24N6O2
M. Wt 452.51
Purity >98%
Synonyms SLx 2119, SLx2119, ROCK inhibitor, KD-025
SMILES CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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