Fig. 1 · Structure
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SM19712 free acid
Endothelin-Converting Enzyme (ECE)
SM19712 free acid is a selective inhibitor of endothelin-converting enzyme (ECE), targeting the conversion of big endothelin to active endothelin-1. This compound has demonstrated significant effects on corticotropin-releasing factor receptor 1 (CRF1) signaling pathways. SM19712 is primarily used in research related to cardiovascular and neuroendocrine regulation, making it a valuable tool for studying endothelin's role in various physiological and pathophysiological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 194542-49-9 |
| Applications | Endothelin-Converting Enzyme (ECE) |
| Formula | C18H14ClN5O3S |
| Molecular Weight | 415.85 |
| SMILES | O=S(C1=CC=C(C=C1)Cl)(NC(NC2=C(C(C)=NN2C3=CC=CC=C3)C#N)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.