Fig. 1 · Structure
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SMA-12b
Immunomodulator
SMA-12b is a small molecule immunomodulator derived from the parasitic worm compound ES-62. It exhibits significant regulatory effects on the expression of genes involved in inflammatory responses, particularly reducing the expression of the cytokine IL-1β. This action is mediated via the NRF2 pathway, effectively inhibiting IL-1β production. SMA-12b is intended for use in research applications focused on rheumatoid arthritis and other autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1496553-39-9 |
| Applications | Immunomodulator |
| Formula | C13H22INO2S |
| Molecular Weight | 383.29 |
| SMILES | O=S(CC[N+](C)(C)C)(CC1=CC=C(C=C1)C)=O.[I-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.