Fig. 1 · Structure
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SMANT hydrochloride
Smo Signaling Inhibitor
SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling. It functions as an antagonist of Smo accumulation within the primary cilium, exhibiting comparable inhibitory activity against both the oncogenic form of Smo (SmoM2) and wild-type Smo. This compound is useful for research applications involving the Hedgehog signaling pathway and has potential implications in studies focused on cancer and developmental biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1177600-74-6 |
| Applications | Smo Signaling Inhibitor |
| Formula | C16H24BrClN2O |
| Molecular Weight | 375.73 |
| SMILES | O=C(NC1=CC=C(Br)C=C1)CCN2CC(C)CC(C)C2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.