Fig. 1 · Structure
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SMARCA2/4-IN-2
Ligand for Target Protein for PROTAC
SMARCA2/4-IN-2 is a ligand specifically designed for the SMARCA2 and SMARCA4 proteins, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the synthesis of PROTAC SMARCA2/4-degrader-5, enabling targeted degradation of these chromatin remodelers. SMARCA2/4-IN-2 is valuable for research applications in cancer biology and therapeutic development focused on modulation of epigenetic regulators.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1339378-93-6 |
| Applications | Ligand for Target Protein for PROTAC |
| Formula | C10H9N3O |
| Molecular Weight | 187.20 |
| SMILES | OC1=CC=CC=C1C2=CC=C(N)N=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.