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SMARCA2 Ligand-Linker Conjugate-4

Target Protein Ligand-Linker Conjugate

SMARCA2 Ligand-Linker Conjugate-4 is designed as a targeted protein ligand-linker conjugate that includes a specific ligand for SMARCA2 along with a PROTAC linker to facilitate the recruitment of E3 ubiquitin ligases. This conjugate is instrumental in the synthesis of PROTAC SMARCA2 degrader-35, enabling the targeted degradation of SMARCA2 protein. Its applications extend to research in protein degradation mechanisms and the modulation of gene expression pathways involved in various diseases.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3033001-29-2
Applications	Target Protein Ligand-Linker Conjugate
Formula	C₂₂H₁₈F₃N₅O₃
Molecular Weight	457.41
SMILES	OC1=C(F)C=CC=C1C2=NN=C3C(N(C[C@H](OC4=NC=C(C=O)C=C4)C5)[C@@]5(C(F)F)CN3)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.