Fig. 1 · Structure
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SMIP34
PELP1 Inhibitor
SMIP34 is a selective inhibitor of PELP1, exhibiting a Kd of 37.4 μM upon binding. It effectively inhibits the proliferation of cancer cells and hinders tumor progression, making it a valuable tool in breast cancer research. SMIP34 demonstrates activity against wild-type and mutant estrogen receptor-positive (ER+) breast cancer, including therapy-resistant variants, facilitating investigations into treatment resistance and novel therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1189710-20-0 |
| Applications | PELP1 Inhibitor |
| Formula | C25H32ClN5O3 |
| Molecular Weight | 486.01 |
| SMILES | O=C(C1=NN2C(C(N(C(C)(C2)C(NC3CCCC3)=O)CCCC)=O)=C1)NC4=CC=C(C)C(Cl)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.