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smMLCK peptide

Catalog No.: A57602
smMLCK Inhibitor
smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK) that functions by mimicking the substrate and competitively inhibiting substrate binding. This mechanism disrupts kinase activity, preventing phosphorylation of the myosin light chain and subsequently inhibiting muscle contraction. It is a valuable tool for studying smooth muscle function and exploring therapeutic strategies for related disorders.
smMLCK peptide 172960-20-2 smMLCK Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionsmMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK) that functions by mimicking the substrate and competitively inhibiting substrate binding. This mechanism disrupts kinase activity, preventing phosphorylation of the myosin light chain and subsequently inhibiting muscle contraction. It is a valuable tool for studying smooth muscle function and exploring therapeutic strategies for related disorders.
Product Information
Catalog NumA57602
FormulaC98H168N38O25
Molecular Weight2278.62
CAS Number172960-20-2
SequenceAla-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-Ser-Ser
Sequence shorteningARRKWQKTGHAVRAIGRLSS
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC([C@H](C)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CO)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)[C@H](CC)C)=O)C)=O)CCCNC(=N)N)=O)C(C)C)=O)C)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3
SynonymsSmooth-Muscle Myosin Light-Chain Kinase (796-815)
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