Fig. 1 · Structure
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SMO-IN-2
SMO Inhibitor
SMO-IN-2 is a potent inhibitor of Smoothened (SMO) with an IC50 value of 123.4 nM, targeting the hedgehog (Hh) signaling pathway. This compound exhibits significant antiproliferative activity against the human medulloblastoma cell line Daoy, demonstrating its potential in anticancer research. SMO-IN-2 is useful for studies exploring the modulation of Hh signaling in various cancer types.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1822355-27-0 |
| Applications | SMO Inhibitor |
| Formula | C25H25F4N5O2 |
| Molecular Weight | 503.49 |
| SMILES | O=C(N(C)C1CCN(C(C2=CC=CC=C2NC3=CC=NN3C)=O)CC1)C4=CC=C(F)C=C4C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.