Fig. 1 · Structure
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SMTIN-T140
TRAP1 Inhibitor
SMTIN-T140 is a selective inhibitor of TRAP1 (tumor-necrosis-factor-receptor associated protein 1) with an IC50 of 1.646 μM. This compound exhibits significant anticancer activity by inducing mitochondrial dysfunction, increasing mitochondrial reactive oxygen species (ROS) production, and activating AMP-activated protein kinase (AMPK). In in vivo studies, SMTIN-T140 effectively suppressed tumor growth in a mouse model xenografted with PC3 prostate cancer cells, demonstrating minimal toxicity. It serves as a valuable tool for investigating TRAP1's role in cancer biology and as a potential therapeutic agent.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2851532-40-4 |
| Applications | TRAP1 Inhibitor |
| Formula | C36H34BrClFN5OP+ |
| Molecular Weight | 718.02 |
| SMILES | NC1=NC(Cl)=C2C(N(C(N2CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=C(C=C(C=C6)Br)F)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.