Fig. 1 · Structure
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SN-38 glucuronide
Inactive Metabolite of Irinotecan
SN-38 glucuronide is an inactive metabolite of the anticancer agent Irinotecan, a topoisomerase I inhibitor. This compound is primarily used in studies focusing on the pharmacokinetics and toxicity of Irinotecan, particularly its adverse effects on the gastrointestinal tract. Research utilizing SN-38 glucuronide contributes to understanding drug metabolism and improving therapeutic strategies for colon and rectal cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 121080-63-5 |
| Applications | Inactive Metabolite of Irinotecan |
| Formula | C28H28N2O11 |
| Molecular Weight | 568.53 |
| Synonyms | SN-38G |
| SMILES | O=C1OCC2=C(C=C(C3=NC4=CC=C(O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O5)C=C4C(CC)=C3C6)N6C2=O)[C@@]1(O)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.