SN003 is a reversible antagonist of corticotropin-releasing factor receptor 1 (CRFR 1), exhibiting an IC50 of 241 nM and over 1000-fold selectivity for CRFR 1 compared to CRFR 2. This compound effectively suppresses corticotropin-releasing factor-induced adrenocorticotropic hormone (ACTH) release in vitro. Additionally, SN003 demonstrates the potential to mitigate depressive-like behavior in rat models, making it a valuable tool for research in neuropsychiatric disorders.
SN003 is a reversible antagonist of corticotropin-releasing factor receptor 1 (CRFR 1), exhibiting an IC50 of 241 nM and over 1000-fold selectivity for CRFR 1 compared to CRFR 2. This compound effectively suppresses corticotropin-releasing factor-induced adrenocorticotropic hormone (ACTH) release in vitro. Additionally, SN003 demonstrates the potential to mitigate depressive-like behavior in rat models, making it a valuable tool for research in neuropsychiatric disorders.
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