Fig. 1 · Structure
Documents & Downloads
SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3
Drug-Linker Conjugate
SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features the potent anti-cancer agent SN38 linked to a proprietary spacer that incorporates a PEG8 moiety, facilitating improved solubility and stability. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is suitable for the synthesis of ADCs through click chemistry, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its design allows for targeted delivery of therapeutics in cancer research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1373170-36-5 |
| Applications | Drug-Linker Conjugate |
| Formula | C78H95N9O20 |
| Molecular Weight | 1478.64 |
| SMILES | O=C1[C@](OC(OCC2=CC=C(NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5)=O)C=C2)=O)(CC)C6=C(CO1)C(N7CC8=C(CC)C9=CC(O)=CC=C9N=C8C7=C6)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.