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Snail IN-1

Snail Inhibitor

Snail IN-1 is a potent inhibitor of the Snail transcription factor, exhibiting a binding affinity (Ka) of 0.36 μM. This compound disrupts the interaction between Snail and CBP, promoting Snail protein degradation, enhancing polyubiquitination, and leading to a selective downregulation of Snail without affecting other epithelial-mesenchymal transition (EMT) transcription factors. Snail IN-1 demonstrates significant anti-inflammatory effects and improves plaque stability by reducing atherosclerotic plaque burden and modulating inflammatory factors such as CCL5, CXCL10, MMP2, and MMP9, while upregulating α-smooth muscle actin. It serves as a valuable tool in researching atherosclerosis and related inflammatory processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3083216-69-4
Applications	Snail Inhibitor
Formula	C₂₁H₂₃N₅O₂S
Molecular Weight	409.50
SMILES	CC1=C(C=CN=C1CSC2=NC3=CC(N4C=CC=N4)=CC=C3N2)OCCCOC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.