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SNAP-6201

α1a Adrenoceptor Antagonist

SNAP-6201 is a selective α1a adrenoceptor antagonist with a binding affinity (Ki) of 0.2 nM, demonstrating over 1400-fold selectivity against α1b and α1d adrenoceptors. This compound effectively decreases intraurethral pressure (IUP) in anesthetized canine models. SNAP-6201 is valuable for research into benign prostatic hyperplasia (BPH) and provides insights into therapeutic interventions targeting α1a adrenoceptor pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	252201-38-0
Applications	α1a Adrenoceptor Antagonist
Formula	C₃₀H₃₅F₂N₅O₅
Molecular Weight	583.63
SMILES	COC(C1(C2=CC=CC=C2)CCN(CCCNC(N3C(NC(CC)=C(C(N)=O)C3C4=CC(F)=C(F)C=C4)=O)=O)CC1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.