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SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
| Target | Value |
|---|---|
| CDK9/CyclinT | IC50: 4nM |
| CDK2/CyclinA | IC50: 38nM |
| CDK2/CyclinE | IC50: 48nM |
| CDK7/CyclinH | IC50: 62nM |
| GSK-3α | IC50: 230nM |
| CDK5/p35 | IC50: 340nM |
| CDK1/CyclinB | IC50: 480nM |
| GSK-3β | IC50: 660nM |
| CDK4/CyclinD | IC50: 925nM |
| CDK6/CyclinD | IC50: >1μM |
| In vitro (25°C) | DMSO | 76 mg/mL (199.72 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.28 mL | 131.41 mL | 262.81 mL |
| 0.5 mM | 5.26 mL | 26.28 mL | 52.56 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10850 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 380.5 |
| Formula | C17H24N4O2S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 345627-80-7 |
| Synonyms | SNS032, BMS-387032, BMS387032 |
| SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3 |
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