SNS-032 (BMS-387032)

Catalog No.: A10850

CDK inhibitor

SNS-032 (BMS-387032)

SNS-032 (BMS-387032) Chemical Structure

CAS NO. 345627-80-7

SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $36.00

10 mg

Regular Price: $60.00

Special Price $54.00

50 mg

Regular Price: $180.00

Special Price $162.00

100 mg

Regular Price: $300.00

Special Price $270.00

10mM * 1mL in DMSO

Regular Price: $89.00

Special Price $80.10

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
Target Value
CDK9/CyclinTIC50: 4nM
CDK2/CyclinAIC50: 38nM
CDK2/CyclinEIC50: 48nM
CDK7/CyclinHIC50: 62nM
GSK-3αIC50: 230nM
CDK5/p35IC50: 340nM
CDK1/CyclinBIC50: 480nM
GSK-3βIC50: 660nM
CDK4/CyclinDIC50: 925nM
CDK6/CyclinDIC50: >1μM
In vitro (25°C) DMSO 76 mg/mL (199.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.28 mL 131.41 mL 262.81 mL
0.5 mM 5.26 mL 26.28 mL 52.56 mL
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10850
Actions Inhibitor
M. Wt 380.5
Formula C17H24N4O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 345627-80-7
Synonyms SNS032, BMS-387032, BMS387032
SMILES CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3

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