Total item
Cart Subtotal
$0.00 Biological Activity
SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
| Target | Value |
|---|---|
| CDK9/CyclinT | IC50: 4nM |
| CDK2/CyclinA | IC50: 38nM |
| CDK2/CyclinE | IC50: 48nM |
| CDK7/CyclinH | IC50: 62nM |
| GSK-3α | IC50: 230nM |
| CDK5/p35 | IC50: 340nM |
| CDK1/CyclinB | IC50: 480nM |
| GSK-3β | IC50: 660nM |
| CDK4/CyclinD | IC50: 925nM |
| CDK6/CyclinD | IC50: >1μM |
| In vitro (25°C) | DMSO | 74 mg/mL (194.46 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.28 mL | 131.41 mL | 262.81 mL |
| 0.5 mM | 5.26 mL | 26.28 mL | 52.56 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10850 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 345627-80-7 |
| Formula | C17H24N4O2S2 |
| M. Wt | 380.5 |
| Purity | >98% |
| Synonyms | SNS032, BMS-387032, BMS387032 |
| SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD 0332991 HCl (Palbociclib)
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activit…
AT7519 HCl
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
NVP-LCQ195
NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
Flavopiridol HCl
Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.
P276-00
P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
Dinaciclib (SCH 727965)
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 …
CVT-313
CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 2…
AT7519
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
Keywords:buy SNS-032 (BMS-387032) | SNS-032 (BMS-387032) Supplier | purchase | cost | manufacturer | order | distributor | buy 345627-80-7| 345627-80-7 Supplier | purchase 345627-80-7 | 345627-80-7 cost | 345627-80-7 manufacturer | order 345627-80-7 | 345627-80-7 distributor
Adooq Quality Guarantee
We promise all products perform as described.