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Biological Activity
SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
Target | Value |
---|---|
CDK9/CyclinT | IC50: 4nM |
CDK2/CyclinA | IC50: 38nM |
CDK2/CyclinE | IC50: 48nM |
CDK7/CyclinH | IC50: 62nM |
GSK-3α | IC50: 230nM |
CDK5/p35 | IC50: 340nM |
CDK1/CyclinB | IC50: 480nM |
GSK-3β | IC50: 660nM |
CDK4/CyclinD | IC50: 925nM |
CDK6/CyclinD | IC50: >1μM |
In vitro (25°C) | DMSO | 74 mg/mL (194.46 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.28 mL | 131.41 mL | 262.81 mL |
0.5 mM | 5.26 mL | 26.28 mL | 52.56 mL |
1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
*The above data is based on the productmolecular weight 380.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10850 |
---|---|
Actions | Inhibitor |
CAS No. | 345627-80-7 |
Formula | C17H24N4O2S2 |
M. Wt | 380.5 |
Purity | >98% |
Synonyms | SNS032, BMS-387032, BMS387032 |
SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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