Fig. 1 · Structure
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Soclenicant
α7 nAChR NAM
Soclenicant (BNC210) is an orally active negative allosteric modulator (NAM) of the α7 nicotinic acetylcholine receptor (nAChR). It demonstrates acute anxiolytic effects in rodent models, making it relevant for research into anxiety, trauma, and stress-related disorders. Soclenicant effectively inhibits α7 nAChR currents induced by acetylcholine, nicotine, choline, and the α7-specific agonist PNU-282987, with IC50 values ranging from 1.2 to 3 μM. This compound presents a valuable tool for investigating the role of α7 nAChRs in neuropsychiatric conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1020634-41-6 |
| Applications | α7 nAChR NAM |
| Formula | C24H26N4O3 |
| Molecular Weight | 418.49 |
| Synonyms | BNC210; IW-2143 |
| SMILES | O=C1C2=CC(NC3CC4=C(C3)C=CC=C4)=CN=C2N(CC)C=C1C(N5CCOCC5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.