Fig. 1 · Structure
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Sonidegib metabolite M48
Sonidegib Metabolite
Sonidegib metabolite M48 is the primary circulating metabolite of the hedgehog pathway inhibitor Sonidegib. M48 exhibits a significantly prolonged Tmax of 60 hours, suggesting a distinct pharmacokinetic profile compared to its parent compound. This metabolite is essential for the investigation of Sonidegib's therapeutic effects and pharmacodynamics in cancer research, particularly in the context of tumors driven by aberrant hedgehog signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1221722-10-6 |
| Applications | Sonidegib Metabolite |
| Formula | C15H11F3O3 |
| Molecular Weight | 296.24 |
| SMILES | O=C(O)C1=C(C(C2=CC=C(C=C2)OC(F)(F)F)=CC=C1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.