Fig. 1 · Structure
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SOP1812
Quadruplex Ligand
SOP1812 (QN-302) is a naphthalene diimide derivative that functions as a quadruplex ligand, exhibiting significant anti-tumor activity. It specifically binds to G-quadruplex structures, leading to the down-regulation of multiple cancer-related gene pathways. Notably, SOP1812 demonstrates high affinity for the hTERT G4 and HuTel21 G4 with dissociation constants (KD) of 4.9 nM and 28.4 nM, respectively. This compound is applicable in cancer research, providing insights into therapeutic targeting of G-quadruplex DNA.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2546091-70-5 |
| Applications | Quadruplex Ligand |
| Formula | C45H57N7O6 |
| Molecular Weight | 791.98 |
| Synonyms | QN-302 |
| SMILES | O=C1C2=CC(NCCN3CCCC3)=C4C(N(CCCN5CCOCC5)C(C6=CC(C7=CC=C(CN8CCCC8)C=C7)=C(C2=C64)C(N1CCCN9CCOCC9)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.