Fig. 1 · Structure
Documents & Downloads
Soquelitinib
ITK Inhibitor
Soquelitinib is a selective covalent inhibitor of interleukin-2-inducible kinase (ITK). It exhibits significant anti-inflammatory activity across multiple models of T cell-mediated inflammatory diseases, including asthma, pulmonary fibrosis, systemic sclerosis, psoriasis, and acute graft-versus-host disease. By inhibiting Th2 cytokine production, Soquelitinib enhances the infiltration of CD8+ T cells into tumors, promoting improved T effector function and potential therapeutic benefits in oncology and immunology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2226636-04-8 |
| Applications | ITK Inhibitor |
| Formula | C25H30N4O4S2 |
| Molecular Weight | 514.66 |
| Synonyms | CPI-818 |
| SMILES | O=C(N1C[C@H](N(CCC1)C(C=C)=O)C)C2=C(C=C(C(SC3=CN=C(NC(C4CC4)=O)S3)=C2)C)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.