Fig. 1 · Structure
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SORT-PGRN interaction inhibitor 1
Sortilin-Progranulin Interaction Inhibitor
SORT-PGRN Interaction Inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction, demonstrating an IC50 of 2 μM. This compound serves as a valuable tool for research into neurodegenerative disorders associated with dysregulation of progranulin. Its ability to inhibit this critical protein-protein interaction allows for further exploration of the underlying mechanisms of disease and potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 100957-85-5 |
| Applications | Sortilin-Progranulin Interaction Inhibitor |
| Formula | C15H18N2O2 |
| Molecular Weight | 258.32 |
| SMILES | O=C(C1=CC(C(C)(C)C)=NN1CC2=CC=CC=C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.