SOS1-IN-21 is a potent inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 plays a critical role in the activation of KRAS by promoting GDP-GTP exchange. SOS1-IN-21 demonstrates significant antiproliferative effects, exhibiting IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell lines. Additionally, it shows substantial antitumor activity in the Mia Paca-2 xenograft model, making it a valuable tool for research on KRAS mutant tumors, including pancreatic cancer.
SOS1-IN-21 is a potent inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 plays a critical role in the activation of KRAS by promoting GDP-GTP exchange. SOS1-IN-21 demonstrates significant antiproliferative effects, exhibiting IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell lines. Additionally, it shows substantial antitumor activity in the Mia Paca-2 xenograft model, making it a valuable tool for research on KRAS mutant tumors, including pancreatic cancer.
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