Fig. 1 · Structure
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Sp-8-Br-cGMPS
CNG Channel Agonist
Sp-8-Br-cGMPS is an analog of cyclic guanosine monophosphate (cGMP) that functions as an agonist for cyclic nucleotide-gated cation channels (CNG channels). With an EC50 value of 106.5 μM, Sp-8-Br-cGMPS induces ionic currents through these channels, although it does not stabilize the open state of the channel like a full agonist would. This compound is valuable for researching CNG channel physiology and the role of cGMP signaling in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 153660-03-8 |
| Applications | CNG Channel Agonist |
| Formula | C10H11BrN5O6PS |
| Molecular Weight | 440.17 |
| SMILES | O=C(NC(N)=N1)C2=C1N(C(Br)=N2)[C@H]3[C@H](O)[C@H](O[P@]4(S)=O)[C@@H](CO4)O3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.