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Sp-8-Cl-cAMPS

Protein Kinase Activator

Sp-8-Cl-cAMPS is a selective activator of protein kinases cAKI and cAKII, exhibiting an affinity of 0.25 μM and 3.2 μM, respectively. This cAMP analog demonstrates significant biological activity, effectively inhibiting the growth of human leukemia cells (HL-60) and colon cancer cells (LS-174T), with IC50 values ranging from 8 to 100 μM. Sp-8-Cl-cAMPS serves as a valuable tool for studying the roles of cAMP-dependent signaling pathways in cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	142754-28-7
Applications	Protein Kinase Activator
Formula	C₁₀H₁₁ClN₅O₅PS
Molecular Weight	379.72
SMILES	S[P@@]1(O[C@H]2[C@@H](O)[C@H](N3C(Cl)=NC4=C3N=CN=C4N)O[C@@H]2CO1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.