Fig. 1 · Structure
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Sp-TTPαS
SAMHD1 Inhibitor
Sp-TTPαS is a competitive inhibitor of the sterile alpha motif and HD domain-containing protein 1 (SAMHD1), targeting its triphosphohydrolase activity. With a Ki value of 46 µM, Sp-TTPαS effectively blocks SAMHD1 hydrolysis, making it a valuable tool for researching cellular mechanisms involving nucleotide metabolism and immune response regulation. This compound is particularly relevant in studies exploring the role of SAMHD1 in viral replication and DNA regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 83199-32-0 |
| Applications | SAMHD1 Inhibitor |
| Formula | C10H17N2O13P3S |
| Molecular Weight | 498.23 |
| SMILES | O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO[P@@](OP(OP(O)(O)=O)(O)=O)(S)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.