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SP100030 analogue 1

SITA Inhibitor

SP100030 analogue 1 is a selective inhibitor of transcriptional activation (SITA) that targets the XPO1 pathway. With an EC50 of 137 nM, it effectively suppresses the XPO1-dependent upregulation of interleukin-2 (IL2) as demonstrated in the Jurkat-based IL2-Luc reporter assay. This compound is valuable for research applications focused on modulating gene expression and exploring therapeutic strategies for immune-related conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	154934-68-6
Applications	SITA Inhibitor
Formula	C₁₃H₅ClF₇N₃O
Molecular Weight	387.64
SMILES	O=C(C1=CN=C(N=C1C(F)(F)F)Cl)NC2=CC(F)=CC(C(F)(F)F)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.