Fig. 1 · Structure
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SPA70
hPXR Antagonist
SPA70 is a potent and selective antagonist of the human pregnane X receptor (hPXR), exhibiting an IC50 value of 540 nM and a Ki of 390 nM. This compound has been shown to enhance the chemosensitivity of cancer cells, making it a valuable tool for research in cancer biology and drug resistance mechanisms. Its role in modulating hPXR activity offers insights into therapeutic strategies for improving cancer treatment efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 931314-31-7 |
| Applications | hPXR Antagonist |
| Formula | C21H25N3O4S |
| Molecular Weight | 415.51 |
| SMILES | CC1=C(S(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)N=NN1C3=CC(OC)=CC=C3OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.