Fig. 1 · Structure
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Sparfosic acid trisodium
Aspartate Transcarbamoyl Transferase Inhibitor
Sparfosic acid trisodium is a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme crucial for the de novo synthesis of pyrimidines. This DNA antimetabolite exhibits significant cytotoxic effects, particularly when used in combination with 5-fluorouracil (5-FU) and interferon-alpha (IFN), enhancing therapeutic efficacy against human colon cancer cell lines. Its ability to disrupt pyrimidine metabolism makes it a valuable tool in cancer research and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 70962-66-2 |
| Applications | Aspartate Transcarbamoyl Transferase Inhibitor |
| Formula | C6H7NNa3O8P |
| Molecular Weight | 321.06 |
| SMILES | O=C(O[Na])C[C@@H](C(O[Na])=O)NC(CP(O)(O[Na])=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.