Fig. 1 · Structure
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Sparfosic acid
Aspartate Transcarbamoyl Transferase Inhibitor
Sparfosic acid acts as a potent inhibitor of aspartate transcarbamoyl transferase, a key enzyme in the de novo pyrimidine biosynthesis pathway. This compound demonstrates significant cytotoxic effects, particularly in combination with 5-fluorouracil (5-FU) and interferon-alpha (IFN), enhancing their effectiveness against human colon cancer cell lines. Due to its mechanism of action, sparfosic acid is valuable for research focused on cancer treatment and metabolic pathway modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 51321-79-0 |
| Applications | Aspartate Transcarbamoyl Transferase Inhibitor |
| Formula | C6H10NO8P |
| Molecular Weight | 255.12 |
| SMILES | O=C(O)C[C@@H](C(O)=O)NC(CP(O)(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.