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Spesolimab
Spesolimab (BI 655130) is a humanized IgG1κ monoclonal antibody derived from mouse sources, targeting the interleukin-36 receptor (IL-36R). IL-36 is critical in mediating immune responses, and Spesolimab has shown potential efficacy in clinical studies for the treatment of palmoplantar pustulosis (PPP). The therapeutic action of Spesolimab includes the modulation of biomarkers linked to innate immunity and Th1/Th17 and neutrophil pathways, suggesting its role in altering inflammatory processes. This antibody is currently under investigation for its therapeutic potential and mechanism of action in immune-mediated dermatological conditions.
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Biological Activity
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2097104-58-8 |
| Molecular Weight | 145500 |
| Synonyms | BI 655130 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.