Fig. 1 · Structure
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SPH5030
HER2 Inhibitor
SPH5030 is a selective and irreversible inhibitor of the HER2 receptor, targeting both HER2WT and EGFRWT with IC50 values of 3.51 nM and 8.13 nM, respectively. This compound demonstrates significant activity against various HER2 mutant forms, making it a valuable tool in cancer research. SPH5030 is useful for studying HER2-related pathways and developing targeted therapies for HER2-positive cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2364326-23-6 |
| Applications | HER2 Inhibitor |
| Formula | C31H31FN8O3 |
| Molecular Weight | 582.63 |
| SMILES | CCOC1=C(C=C2C(N=CN=C2NC3=CC(C)=C(C=C3)OC4=CC5=NC=NN5C=C4)=C1)NC(/C(F)=C/[C@H]6CCCN6C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.