Fig. 1 · Structure
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SPI-05
SENP1 Inhibitor
SPI-05 is a non-competitive inhibitor of SENP1, a SUMO-specific protease, with an IC50 of 60 μM. This compound shows potential in cancer research, particularly in prostate cancer and hypoxia-driven solid tumors where SENP1 is overexpressed. Its ability to modulate SUMOylation processes makes SPI-05 a valuable tool for investigating the role of SENP1 in cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 5463-64-9 |
| Applications | SENP1 Inhibitor |
| Formula | C34H26N6O6S2 |
| Molecular Weight | 678.74 |
| Synonyms | NSC 5067 |
| SMILES | NC1=CC=C(C2=C1C=CC=C2)/N=N/C(C=C3)=CC([S](=O)(O)=O)=C3/C=C/C(C=CC(/N=N/C(C4=C5C=CC=C4)=CC=C5N)=C6)=C6[S](=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.