Fig. 1 · Structure
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(±)-Spiro-oxanthromicin A
K-Ras Inhibitor
(±)-Spiro-oxanthromicin A is a K-Ras inhibitor with an IC50 value of 26.7 μM. This polyketide compound is derived from soil-isolated Streptomyces sp. and has been shown to mislocalize oncogenic mutant K-Ras from the plasma membrane in intact MDCK cells. (±)-Spiro-oxanthromicin A serves as a valuable tool for cancer research, particularly in studies targeting K-Ras-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1616622-10-6 |
| Applications | K-Ras Inhibitor |
| Formula | C36H26O10 |
| Molecular Weight | 618.59 |
| SMILES | CC(C=C1C(C(C2=C3O)=CC=C3C)(CC=C(C(C4=C5C)=CC(O)=C5C(O)=O)C1=C6C4=O)C(C(C2=O)=C7C)=CC(O)=C7C(O)=O)=C6O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.