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Biological Activity
SPL-B, Orally active inhibitor of transforming acidic coiled-coil protein (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells, without affecting spindle assembly in normal cells.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22 mL | 110.02 mL | 220.03 mL |
| 0.5 mM | 4.4 mL | 22 mL | 44.01 mL |
| 1 mM | 2.2 mL | 11 mL | 22 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
*The above data is based on the productmolecular weight 454.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16085 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1465248-60-5 |
| Formula | C27H22N2O5 |
| M. Wt | 454.48 |
| Purity | >98% |
| Synonyms | Spindlactone B |
| SMILES | CCN(CC1=CC=NC=C1)CC2=C(C=CC3=C2OC(=O)C=C3C4=CC5=CC=CC=C5OC4=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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