Spliceostatin A

Catalog No.: A12700

Spliceostatin A

Spliceostatin A Chemical Structure

CAS NO. 391611-36-2

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

Availability: Out of stock

Package Price
1 mg
$800.00
2 mg
$1,500.00
5 mg
$3,000.00
10 mg
$5,000.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Arfaoui A, .et al. A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells, EMBO Mol Med, 2019, Oct;11(10):e9930 PMID: 31476112
  • KE Mengwasser, .et al. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets, ‎Mol Cell, 2019, S1097-2765(18)31062-1 PMID: 30686591
  • Sahar AlShareef, .et al. Herboxidiene triggers splicing repression and abiotic stress responses in plants, BMC Genomics, 2017, 18: 260 PMID: 28347276
  • Ling Y, .et al. Pre-mRNA splicing repression triggers abiotic stress signaling in plants, Plant J, 2017, Jan;89(2):291-309 PMID: 27664942
  • Matthew J. Hangauer, .et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition, Nature, 2017, Nov 9; 551(7679): 247–250. PMID: 29088702
  • Ji Hyun Kim, .et al. Mitotic control by mRNA splicing regulators ensures primary cilia formation, Animal Cells and Systems, 2017, 21:1, 17-22 PMID: 30460047
  • M Tanikawa, .et al. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing, Oncogenesis, 2016, Dec; 5(12): e280 PMID: 27991914
  • Ji Hyun Kim, .et al. Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation, Biochim Biophys Acta, 2016, Jun; 1863(6 Pt A): 1307–1318 PMID: 27033521

Biological Activity

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.17 mL 95.85 mL 191.7 mL
0.5 mM 3.83 mL 19.17 mL 38.34 mL
1 mM 1.92 mL 9.58 mL 19.17 mL
5 mM 0.38 mL 1.92 mL 3.83 mL

*The above data is based on the productmolecular weight 521.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12700
M. Wt 521.65
Formula C28H43NO8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 391611-36-2
SMILES C[[email protected]]1C[[email protected]]([[email protected]](O[[email protected]]1C/C=C(\C)/C=C/[[email protected]@H]2[[email protected]]([[email protected]@]3(C[[email protected]@](O2)(C)OC)CO3)O)C)NC(=O)/C=C/[[email protected]](C)OC(=O)C

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