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Spliceostatin A

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Catalog No. A12700
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Availability: Out of stock

Product Name Catalog No. Price
Spliceostatin A 1mg A12700-1
Spliceostatin A 2mg A12700-2
Spliceostatin A 5mg A12700-5
Spliceostatin A 10mg A12700-10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

Spliceostatin A

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Publications citing Adooq Products
Spliceostatin A Citations (6)
  • Sahar AlShareef,et al. Herboxidiene triggers splicing repression and abiotic stress responses in plants, BMC Genomics, 2017, 18: 260 28347276
  • Ling Y,et al. Pre-mRNA splicing repression triggers abiotic stress signaling in plants, Plant J, 2017, Jan;89(2):291-309 27664942
  • Matthew J. Hangauer,et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition, Nature, 2017, Nov 9; 551(7679): 247-250. 29088702
  • Ji Hyun Kim,et al. Mitotic control by mRNA splicing regulators ensures primary cilia formation, Animal Cells and Systems, 2017, 21:1, 17-22 30460047
  • M Tanikawa,et al. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing, Oncogenesis, 2016, Dec; 5(12): e280 27991914
  • Ji Hyun Kim,et al. Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation, Biochim Biophys Acta, 2016, Jun; 1863(6 Pt A): 1307-1318 27033521

Chemical Information

Catalog Num A12700
Actions No
M. Wt 521.65
Formula C28H43NO8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 391611-36-2
Synonyms N/A
SMILES code C[[email protected]]1C[[email protected]]([[email protected]](O[[email protected]]1C/C=C(\C)/C=C/[[email protected]@H]2[[email protected]]([[email protected]@]3(C[[email protected]@](O2)(C)OC)CO3)O)C)NC(=O)/C=C/[[email protected]](C)OC(=O)C
Chemical Name N/A

Biological Activity

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.17 mL 95.85 mL 191.7mL
0.5 mM 3.83 mL 19.17 mL 38.34 mL
1 mM 1.92 mL 9.58 mL 19.17 mL
5 mM 0.38 mL 1.92 mL 3.83 mL

*The above data is based on the productmolecular weight 521.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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