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SR-THAP

hGAT3 Inhibitor

SR-THAP is a selective inhibitor of the human γ-aminobutyric acid transporter 3 (hGAT3), demonstrating an IC50 of 4.9 μM and exhibiting 42-fold and 23-fold selectivity over GAT1 and GlyT1, respectively. This compound effectively inhibits GABA uptake in mammalian cells, making it a valuable tool in the study of neurological disorders. SR-THAP is particularly relevant for research into epilepsy, Alzheimer's disease, and ischemic stroke.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3098361-74-8
Applications	hGAT3 Inhibitor
Formula	C₃₁H₃₅NO₆
Molecular Weight	517.61
SMILES	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)/C=C/CN4CCC[C@]4([H])[C@@H](C(O)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.