Fig. 1 · Structure
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SRI-29329
CLK Inhibitor
SRI-29329 is a selective CLK inhibitor, demonstrated to effectively inhibit CLK1, CLK2, and CLK4 with IC50 values of 78 nM, 16 nM, and 86 nM, respectively. This compound is valuable for research into the regulation of pre-mRNA splicing and circadian rhythms, offering potential insights into various biological processes and diseases. Its specificity allows for targeted studies in the modulation of clock gene expression and related therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2086809-58-5 |
| Applications | CLK Inhibitor |
| Formula | C20H26ClN7 |
| Molecular Weight | 399.92 |
| SMILES | CC(N1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[C@H]4CCCC[C@@H]4N)N=C12)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.