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SRI-29574

Dopamine Transporter Allosteric Modulator

SRI-29574 is an allosteric modulator of the dopamine transporter (DAT), exhibiting a partial inhibitory effect on DAT uptake with an IC50 of 2.3 nM. Additionally, it demonstrates partial inhibition of the serotonin transporter (SERT) and norepinephrine transporter (NET). This compound is a valuable tool for investigating the function and regulatory processes associated with DAT, contributing to research in neuropharmacology and the study of mood and anxiety disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1928712-46-2
Applications	Dopamine Transporter Allosteric Modulator
Formula	C₂₉H₂₃N₅
Molecular Weight	441.53
SMILES	C1(C2=CN3C(C=C2)=NC=C3)=NC(NCC(C4=CC=CC=C4)C5=CC=CC=C5)=C6C=CC=CC6=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.