Fig. 1 · Structure
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SRI-31142
Dopamine Transporter
SRI-31142 is an allosteric inhibitor targeting the dopamine transporter (DAT), designed to penetrate the blood-brain barrier. This compound has demonstrated the ability to reduce intracranial self-stimulation (ICSS) responses and lower dopamine levels in the nucleus accumbens (NAc), differentiating its effects from those of traditional stimulants such as cocaine. Additionally, SRI-31142 effectively mitigates cocaine-induced increases in both ICSS and NAc dopamine levels, making it a valuable tool for investigating dopamine-related disorders and exploring potential therapeutic avenues.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1940118-04-6 |
| Applications | Dopamine Transporter |
| Formula | C29H24N6 |
| Molecular Weight | 456.54 |
| SMILES | CC1=CC2=NC=CN2C=C1C3=NC(NCC(C4=CC=CC=C4)C5=CC=NC=C5)=C6C=CC=CC6=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.