Fig. 1 · Structure
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SRI-37240
PTCs Inhibitor
SRI-37240 is a potent inhibitor of premature termination codons (PTCs), specifically designed to suppress CFTR nonsense mutations. This compound effectively alters cellular translation termination at PTCs in HEK293T cells. Additionally, SRI-37240 has demonstrated the ability to restore CFTR function in primary bronchial epithelial cells, particularly when used in combination with G418, making it a valuable tool for research on genetic disorders related to CFTR dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 883956-47-6 |
| Applications | PTCs Inhibitor |
| Formula | C24H23N3O2 |
| Molecular Weight | 385.46 |
| SMILES | O=C1C2=C(N(C)C(N=C(N3C4CCCCC4)C5=CC=CC=C5)=C1C3=O)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.