Fig. 1 · Structure
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SRI-42127
HuR Translocation Inhibitor
SRI-42127 is a selective HuR translocation inhibitor that interferes with the binding of HuR to adenine-rich elements (AREs) in mRNA. By destabilizing mRNA and inhibiting gene promoter activation, SRI-42127 effectively reduces the production of inflammatory cytokines in glial cells. Additionally, this compound suppresses microglial cell activation and attenuates the recruitment and chemotaxis of neutrophils and monocytes, making it a valuable tool for studying inflammatory processes in neurological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2727872-68-4 |
| Applications | HuR Translocation Inhibitor |
| Formula | C19H20N6O |
| Molecular Weight | 348.40 |
| SMILES | CN(C1CCOCC1)C2=NN3C(C=C2)=NC=C3C4=CC5=C(C=C4)C=NN5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.