SS47

Catalog No.: A65747
PROTAC HPK1 Degrader
SS47 is a PROTAC-based HPK1 degrader that facilitates proteasome-mediated degradation of the HPK1 protein. By targeting HPK1 for destruction, SS47 significantly enhances antitumor efficacy, making it a valuable tool for cancer research. Its applications include investigating the role of HPK1 in tumorigenesis and evaluating the efficacy of targeted protein degradation strategies in oncology.
Grouped product items
Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSS47 is a PROTAC-based HPK1 degrader that facilitates proteasome-mediated degradation of the HPK1 protein. By targeting HPK1 for destruction, SS47 significantly enhances antitumor efficacy, making it a valuable tool for cancer research. Its applications include investigating the role of HPK1 in tumorigenesis and evaluating the efficacy of targeted protein degradation strategies in oncology.
Product Information
Catalog NumA65747
FormulaC49H56N6O12S
Molecular Weight953.07
CAS Number2636072-62-1
SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCC(N4CCC(C5=NC=C(C6=CC(OCC7=CC=CC(C#CC(C)(O)C)=C7)=C(N)N=C6)S5)CC4)=O)=O
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