Fig. 1 · Structure
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SSR180711 hydrochloride
α7 n-AChRs Partial Agonist
SSR180711 hydrochloride is a selective and reversible partial agonist of the α7 nicotinic acetylcholine receptors (n-AChRs). It demonstrates significant biological activity with Ki values of 22 nM and 14 nM for rat and human α7 n-AChRs, respectively. This compound enhances glutamatergic neurotransmission, acetylcholine release, and promotes long-term potentiation (LTP) in the hippocampus, making it a valuable tool for research in neuropharmacology and cognitive function studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 446031-79-4 |
| Applications | α7 n-AChRs Partial Agonist |
| Formula | C14H18BrClN2O2 |
| Molecular Weight | 361.66 |
| SMILES | O=C(N1CCN2CCC1CC2)OC3=CC=C(Br)C=C3.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.