Fig. 1 · Structure
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STL001
FOXM1 inhibitor
STL001 is a potent and selective inhibitor of FOXM1, a transcription factor implicated in cellular proliferation and tumorigenesis. This compound induces the translocation of nuclear FOXM1 to the cytoplasm, subsequently promoting its autophagic degradation. STL001 has shown potential to sensitize various human cancers to a wide range of cancer therapies, making it a valuable tool for cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3047493-70-6 |
| Applications | FOXM1 inhibitor |
| Formula | C27H23N7O4 |
| Molecular Weight | 509.52 |
| SMILES | O=C(C1=CC=CO1)OC2=CC(C3=NN(C=C3)C4=NC(NC5=CC=CC=C5)=NC(N6CCOCC6)=N4)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.